Cells with the highest energy demands , such as the heart contain the highest concentration of CoQ10.

Unfortunately as we age, the ability to absorb and synthesis CoQ10 diminishes and the amount of CoQ10 retained in tissues decreases.

In addition CoQ10 maybe depleted by several other factors, including overall nutritional status, CoQ10 maybe lowered by some drugs, including cholestrol-lowering statins, and excessive exercise or enviormental stresses such as illness and extreme weather